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Calcium Phosphates
Univar Solutions Pharmaceutical Ingredients has proudly partnered with Innophos as an authorized European distributor of calcium phosphate excipients and minerals.
Innophos has been manufacturing calcium phosphates at their Chicago Heights, Illinois manufacturing plant since the 1930s. Because of their commitment to meeting the pharmaceutical industry's need for high-performance excipients, they have continually improved their products and their plant's manufacturing capabilities. They have continued to add to their product line to establish their position as a market leader in calcium phosphates.
As an excipient and nutraceutical ingredient, Innophos calcium phosphates help to give you the flexibility to deliver calcium and phosphorus with the most effective combination of dissolution, bioavailability, and mouthfeel to make your formulations a market success.
As a global leader in the distribution of specialty chemicals and ingredients, Univar Solutions brings best-in-class solutions, industry-leading services and market knowledge to support Innophos' product portfolio.
To manufacture calcium phosphates, very pure food grade phosphoric acid is used. The phosphoric acid is reacted with calcium hydroxide, Ca(OH)2, which comes from limestone (CaCO3). The products are precipitated from solution.
When Ca(OH)2 is added to phosphoric acid in the appropriate ratio, the products are monocalcium phosphate or dicalcium phosphate. When acid is added to the calcium hydroxide, the precipitate is tricalcium phosphate. As defined in the USP/NF, tricalcium phosphate is a variable mixture of calcium phosphates, having the approximate composition 10CaO•3P2O5•H2O. This composition corresponds to the formula Ca5(OH)(PO4)3 or Ca10(OH)2(PO4)6.
TRI-TAB® is this material in the granular form. The manufacturing process general equations are shown to the right.
A-Tab® and Di-Tab® Calcium Phosphates are manufactured at Innophos' Chicago Heights plant using calcium oxide (lime) and phosphoric acid. During the synthesis, phosphoric acid and calcium hydroxide are reacted to make dicalcium phosphate which precipitates as a crystalline product. The resulting crystals are dried and screened. No nitrites or nitrosating agents are used in the manufacturing process of these products. However, traces of nitrites may be present from the raw materials and water used in the manufacturing process.
Innophos is the culmination of over a century of advancement in phosphate technology. Their phosphate technologies have provided texture, mineral fortification, enhanced color and flavor to a wide variety of foods, dairy products, and pharmaceuticals.
With over 50 years experience in calcium phosphate excipients, Innophos has become a recognized leader in the field, their ongoing research and development helps to ensure that each batch meets their standards for the highest level of purity and consistency, for all grades and applications.
Industries
This can contain industry information or supplemental information such as tables and charts
This can contain industry information or supplemental information such as tables and charts
Product Information
DI-TAB®: Dicalcium phosphate, dihydrate, unmilled, USP/FCC grades. The most well-known of Innophos's directly compressible excipients, it is used in major vitamin and mineral formulations, in over-the-counter drugs and in prescription drugs.
TRI-TAB®: Tricalcium phosphate, anhydrous, granular, NF/FCC grade. TRI-TAB® has the highest percentage of calcium and is used in calcium supplements.
A-TAB®: Dicalcium phosphate, anhydrous, granular, USP/FCC grade. It is anhydrous (giving it good storage stability), very compressible and provides a high level of calcium and phosphorus.
Innophos calcium phosphates are most effectively used in direct compression tableting. This three-step procedure - which consists of weighing (actives and excipients), mixing and compressing - is all that is required to manufacture a wide variety of tablets.
Calcium Phosphate Product | Calcium Content % | Phosphorus Product Content (%) | Compressibility | Applications |
DI-TAB® dicalcium dihydrate granular | 23 | 18 | Very good | Many – The workhorse of the dietary supplement industry for over 30 years |
A-TAB® dicalcium anhydrous granular | 29 | 22 | Best | Ideal for small tablets and where added tablet stability is needed |
TRI-TAB® tricalcium anhydrous granular | 38 | 17 | Good | Perfect for products where higher calcium content is desired |
TCP-DC™ tricalcium phosphate for direct compression | 35 | 16 | Excellent – directly compressible formulas with TRI-TAB® | Chewable tablets, antacids andcalcium supplements |
Calipharm-D®: Dicalcium phosphate, dihydrate, powder, USP/FCC.
Calipharm-T®: Tricalcium phosphate, anhydrous, powder, NF/FCC.
Calipharm-A®: Dicalcium phosphate, anhydrous, powder, USP/FCC.
The powder forms of calcium phosphates can be used in a wet granulation with a variety of commonly used binders, starches, gums, cellulosics and other polymers. Their water and solvent insolubility make the calcium phosphates ideal for wet granulation.
Calcium Phosphate Product | Calcium Content % | Phosphorus Product Content (%) | Compressibility | Applications |
Calipharm® D dicalcium dihydrate powder | 23 | 18 | - | Ideal for nutritional drinks, vitamin premixes, triturations |
Calipharm® A dicalcium anhydrous powder | 29 | 22 | - | Excellent for chewable multivitamins, vitamin premixes |
Calipharm® T tricalcium anhydrous powder | 38 | 17 | - | Choice for calcium phosphorus fortifications |
Products Available
Product Name | Supplier | Package Type | Weight | Price (UOM) | Price (Package) | ||
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CALIPHARM A EP 25KG PAPER BAG | INNOPHOS | PAPER BAG | 25.00 kgs | -- |
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CALIPHARM D EP 25KG PAPER BAG | INNOPHOS | PAPER BAG | 25.00 kgs | -- |
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A-TAB EP 25KG PAPER BAG | INNOPHOS | PAPER BAG | 25.00 kgs | -- |
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CAL-RISE 25KG PAPER BAG | INNOPHOS | PAPER BAG | 25.00 kgs | -- |
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DI-TAB EP 25KG PAPER BAG | INNOPHOS | PAPER BAG | 25.00 kgs | -- |
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TRI-TAB EP 25KG PAPER BAG | INNOPHOS | PAPER BAG | 25.00 kgs | -- |
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CALIPHARM T 20KG PAPER BAG | INNOPHOS | PAPER BAG | 20.00 kgs | -- |
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CALIPHARM D EP 25KG PAPER BAG | INNOPHOS | PAPER BAG | 25.00 kgs | -- |
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